The Danube River is one of Europe's important waterways, it travels 2857km through or past ten countries, numerous urban centers, an agricultural valley. Therefore, Danube River is also classified as an "international waterway". However, human activities have caused many impacts, such as the change of waters regime and pollution in the Danube River. Human activities, such as drinking water supply, maritime navigation, agriculture, and tourism have caused the change of regime in the Danube River. The high waters regime has caused the floods, and the low waters regime has caused the drought and pond depletion. In addition, human activities such as dumping, littering, and domestic animal have caused pollution. Discarding materials directly into a river, such as car oil, trash, waste of livestock, and antifreeze, contributes to the extensive pollution. Extensive pollution has made most of the Danube river water unsafe to drink. Moreover, polluted water will be too expensive to purify. Although ICPDR has been established to sustain water management, control pollution, and control floods, it is unable to stop the Danube river taking a turn for the worse since only some states purify water from Danube tributaries.